The Radiology Assistant : Crohn's disease (2023)

Carl Puylaert, Jeroen Tielbeek and Jaap Stoker

the Academic Medical Centre, Amsterdam, the Netherlands


In this article we will discuss the MRI-features used to evaluate Crohn's disease of the small bowel and the colon.

A systematic approach is presented to grade disease activity resulting in a simple classification of mild, moderate and severe disease.
This is sufficient for most therapeutic decisions.


The Radiology Assistant : Crohn's disease (1)

Crohn's disease is characterized by inflammatory lesions in the gastrointestinal tract, most commonly in the terminal ileum and colon.
The lesions are usually transmural, which can lead to complications like stenoses, fistulas and abscesses.

While most patients first present with inflammation only, about two thirds of patients will develop complications within 10 years (1).

There is no cure for Crohn's disease.
Immunosuppressive drugs can decrease disease activity, maintain remission and prevent relapse.
Eventually 90% of patients with ileocolic disease require surgery (2).

MRI protocol

The Radiology Assistant : Crohn's disease (2)

Bowel distention
There are two techniques to acquire distension of the small bowel:

  • MR enterography: oral administration of contrast.
  • MR enteroclysis: administration of contrast via a nasojejunal tube.

We routinely perform MR enterography as it suffices in the large majority of patients while being less burdensome and more time efficient.

Oral contrast
For oral contrast several options are available.
We use a Mannitol in water solution (2%), which provides good contrast between lumen and bowel wall on both T1 and T2 sequences and is well accepted by patients.
There is one precaution: no colonoscopy with electrocoagulation should be performed directly after the MRI because of methane resulting from Mannitol breakdown.

MRI sequences
We use the following sequences:

  • Balanced FFE (axial and/or coronal) in breath-hold
  • T2 with fat sat (axial) in breath-hold
  • T1 pre- and post-contrast (axial/coronal) in breath-hold

Optional sequences:

  • T2-FSE without fat sat for additional overview and comparison with T2 with fat sat.
  • Diffusion Imaging (DWI).
  • Balanced FFE cine-study for motility.

Grading Crohn's disease activity

The Radiology Assistant : Crohn's disease (3) Click for enlarged view

There are several systems for grading disease activity in Crohn's disease.

The scoring system, that we use, grades disease activity into none, mild, moderate and severe.

It is based on the score of the bowel wall abnormalities and the presence of complications as presented in the table (3).

Additional findings
Other findings that should be mentioned in the radiology report are:

  • Location of the lesions
  • Exact wall thickness
  • Length of the disease
  • Ulcerations
  • Comb sign
  • Creeping fat
  • Loss of haustration of the colon
  • Partial stenosis
  • Sinus tracts

MRI signs of Crohn's disease

The Radiology Assistant : Crohn's disease (4) Bowel wall thickening with deep ulceration (arrow) in the transverse colon.

Bowel wall thickness

With adequate distension the normal bowel wall has a thickness of 1-3 mm.
A common categorization is 3-5 mm for mild thickening, 5-7 mm for moderate thickening and > 7 mm for marked thickening of the bowel wall.

T1 weighted post-contrast images or non fatsat T2 weighted images (if available) are preferable for measurement of bowel wall thickness.

The image is a coronal post-contrast T1 weighted image showing disease activity in the transverse colon with marked wall thickening of more than 7 mm and deep ulceration (arrow).

The Radiology Assistant : Crohn's disease (5) Balanced FFE image shows marked bowel wall thickening and luminal narrowing of the terminal ileum. Measurement on the balanced FFE sequence can be less accurate due to the black border artifact (arrows).

Increased bowel wall thickness is one of the most common signs of inflammatory activity, but not specific for Crohn's disease.

For more information on the differential diagnosis of bowel wall thickening click here.

Bowel wall thickness correlates well with the severity of the disease activity.

Measurements are best performed on the sequence with good luminal distension.

Black border artifacts on balanced FFE sequences can distort thickness measurements.

The Radiology Assistant : Crohn's disease (6) Thickened terminal ileum segment with marked enhancement on axial post-contrast T1W image with fatsat.


Abnormal bowel wall enhancement after administration of gadolinium is the result of increased vascular permeability and angiogenesis.
It is seen both in active disease and fibrosis.

Enhancement can be graded by comparing to the precontrast images, to normal bowel loops and nearby vascular structures.

  • No abnormal enhancement
    Equivalent to normal bowel wall
  • Minor increased enhancement
    More than normal bowel wall, but significantly less than nearby vascular structures
  • Moderate enhancement
    Somewhat less than nearby vascular structures
  • Marked enhancement
    Equal or more intense than nearby vascular structures

The Radiology Assistant : Crohn's disease (7)

Pattern of enhancement

Enhancement of the bowel wall can be categorized in one of the following patterns:

  1. Homogeneous
  2. Mucosal
  3. Layered

The latter two enhancement patterns can only be appreciated when the wall is thickened.

There is some discussion about the value of the enhancement pattern.

A layered pattern is regarded to depict more severe disease activity compared to the mucosal pattern, which in turn is more severe than a homogeneous pattern (4).

However, different degrees of inflammation and fibrosis can be present at the same time and a layered pattern of enhancement has also been associated with fibrosis (5), although a more recent study did not find this association (6).

The Radiology Assistant : Crohn's disease (8)

Homogeneous enhancementStrong homogeneous enhancement is seen in active inflammation.

The image shows a terminal ileum with a homogeneous enhancement pattern with moderate (green arrow) and marked (red arrow) enhancement on an axial post-contrast T1 image.

The Radiology Assistant : Crohn's disease (9) Mucosal enhancement pattern

Mucosal enhancement

This is seen as bowel wall thickening with increased enhancement of the mucosal layer relative to the outer layers.

The image is a post-contrast T1 image with a mucosal enhancement pattern in the terminal ileum (arrow).

There is relatively low enhancement of the middle and outer layers

The Radiology Assistant : Crohn's disease (10) Layered enhancement pattern of the rectum with some surrounding fat stranding on an axial post-contrast T1 image (arrow). Continued inflammation with a homogeneous enhancement pattern can be seen in the sigmoid colon (green arrow). Also, a right-sided adnexal cyst is present with enhancing rim (arrowheads).

Layered enhancementpattern

This pattern suggests severe disease activity or longstanding chronic disease (4,5).

The three-layered appearance is caused by strong enhancement of the mucosa and the serosa with no enhancement of the middle layer, which is the submucosa and the muscular layer.

This middle layer can consist of fat, edema or fibrotic tissue.
This can be distinguished using a fat sat T2 sequence.

The Radiology Assistant : Crohn's disease (11) Actively inflamed terminal ileum with marked thickening and moderate mural signal intensity (mural edema) on an axial T2 with fat sat.

T2 mural signal intensity

Increased mural signal intensity on fat-saturated T2 images indicates the presence of mural edema, suggesting active disease.

Presence of bowel wall thickening with a low mural T2 signal intensity is more suggestive of fibrotic disease.
The psoas muscle can be used as a reference when assessing mural T2 signal.

Fat suppression is routinely used to differentiate between mural fat depositions and mural edema.
Fat depositions are the result of chronic bowel inflammation and therefore quite common in Crohn's disease.
However, its presence does not indicate active disease.

Perimural edema or fluid can be identified as well and is associated with active disease (7).

The Radiology Assistant : Crohn's disease (12) Inflamed small bowel showing wall thickening and mild mural T2 signal (arrow) on an axial T2 with fat sat. Prestenotic dilatation can be seen proximally of the diseased segment.

T2 mural signal intensity can be graded as follows using a T2 sequence with fat sat:

  • No increase
    normal bowel wall
  • Minor increase
    bowel wall appears dark gray

  • Moderate increase
    bowel wall appears light gray

  • Marked increase
    bowel wall contains areas of white high signal approaching that of luminal content.

The Radiology Assistant : Crohn's disease (13) Wall thickening of the terminal ileum in a 67-year-old male with Crohn's disease since 11 years. Layered enhancement is seen on an axial post-contrast T1 image with fat sat (left). T2 with fat sat (middle) shows the same pattern with a middle layer of low intensity. T2 without fat sat shows an increased signal in the middle layer, suggesting fat depositions. Endoscopy showed only superficial disease.

Fat suppression is routinely used to differentiate between mural fat depositions and mural edema.

Fat depositions are a result of chronic bowel inflammation, but not typical of active disease.

These fat depositions can be diffuse but can also present as a layered pattern.

The CT equivalent for this pattern is the 'fat-halo sign'.

The Radiology Assistant : Crohn's disease (14) Coronal post-contrast T1 and T2 fat sat images show multiple small ulcerations in the terminal ileum.


Moderate to deep ulceration can be seen on T1 and T2 images, but small ulcerations can be difficult to distinguish from mucosal folds depending on the degree of luminal distension.

Ulcerations are active spots of inflammation and usually there is increased enhancement on the post-contrast T1 images.

The Radiology Assistant : Crohn's disease (15)

Loss of haustration

When the colon is involved in Crohn's disease a decrease of haustral folds can be seen.

A complete loss of haustration results in a smooth surface.

This is also a common finding in ulcerative colitis and known as 'lead pipe' colon.

The coronal post-contrast T1 image shows loss of haustral folds throughout the colon in a patient with chronic Crohn's disease.

The Radiology Assistant : Crohn's disease (16) Coronal post-contrast T1 image shows marked enhancement of the terminal ileum with a prominent comb sign.

Comb sign

Increased vascularity of the mesentery is seen in active inflammation.
The engorged vessels have a linear appearance, resembling the teeth of a hair comb (comb sign).

The Radiology Assistant : Crohn's disease (17)

Creeping fat

Creeping fat, also called fibrofatty proliferation or fat wrapping, are different names for hypertrophy of the subserosal fat.

It is a common finding in longstanding Crohn's disease.

The image shows creeping fat surrounding the descending colon.
It isolates the colon from surrounding bowel loops.

The Radiology Assistant : Crohn's disease (18)

Skip lesions

Skip lesions and patchy inflammation are a typical finding in Crohn's disease, in contrast to the continuous inflammation, which is seen in ulcerative colitis.

Skip lesions refers to the interspersed inflammation "skipping" parts of the bowel, which are left unaffected (green arrows).

The coronal T1 post-contrast image (left) and the T2 image (right) show skip lesions in the terminal ileum.
The affected lesions show increased enhancement with a layered pattern (yellow arrows), while another part is unaffected or skipped (green arrows).


The Radiology Assistant : Crohn's disease (19) Coronal post-contrast T1 image with a stenosis at the ileocecal junction (left). No obvious pre-stenotic dilatation is seen. The stenosis was non-passable using endoscopy (right).


Stenosis can present as bowel wall thickening combined with lumen narrowing.
The presence of a prestenotic dilatation increases the likelihood of a stenosis.
Abnormal contrast enhancement of the affected bowel segment is usually present.

In the grading system, only severe stenosis is included as a complication, which is defined as a stenosis with prestenotic dilatation and a moderate-to-marked increase in mural T2 signal.

Narrowing can be due to contraction and therefore check other sequences before making the diagnosis of a stenosis.

There may be a role for motility sequences to demonstrate the presence or absence of motility to differentiate a contraction from a stenosis.

The video shows a motility sequence (BTFE dynamic) showing wall thickening in the cecum and terminal ileum.
There is some decreased motility in the terminal ileum, but there is no stenosis.

The Radiology Assistant : Crohn's disease (20)

Post-contrast T1 images. There are stenoses in the descending and transverse colon.

A 48-year-old female, who was under anti-TNF treatment, underwent a colonoscopy.
In the sigmoid colon, a stenosis was seen, which could not be passed.

MR-enterography was performed to examine the extension of the stenosis.

Scroll through the images.

The small bowel is normal, but stenotic segments are seen in the descending and transverse colon.
Both stenotic segments display wall thickening up to 8 mm and marked enhancement with a mucosal pattern in the descending colon and a layered pattern in the transverse colon.
A prestenotic dilatation is seen before both segments.

Since these stenoses were not present at a colonoscopy before anti-TNF treatment, they had most likely developed during the treatment.

Therefore it was decided to perform a subtotal colectomy with an ileosigmoïdal anastomosis.

The Radiology Assistant : Crohn's disease (21) Post-contrast T1 image of a patient with a large infiltrate involving multiple small bowel loops.


Infiltrate can be seen as creeping fat between bowel loops with replacement of the fat signal intensity and tethering and kinking of bowel loops.

Obstructive symptoms due to adhesions, inflammatory narrowing or fibrosis are common.

Fistulas and abscesses are often present.
Due to the complex structure, the exact path of a fistula can be difficult to define.

The Radiology Assistant : Crohn's disease (22) Coronal Balanced FFE image shows an enterovesical fistula (arrow) originating from the small bowel. Post-contrast T1 image shows marked enhancement of the small bowel and the 'tram track' at the site of the fistula.


Sinus tracts and fistulas are common complications in patients with Crohn's disease.
Both show marked enhancement on T1 images after administration of gadolinium.
A fistulous track can present with a layered 'tram track' configuration or as a linear enhancing structure.

It can be seen going from one bowel loop to another bowel loop, to another hollow organ or to the skin.

The Radiology Assistant : Crohn's disease (23)

Multiple fistulas in the terminal ileum on post-contrast T1 images (arrows). The terminal ileum shows wall thickening (12 mm) and marked enhancement with a layered pattern.

A 50 year-old female with Crohn's disease since 10 years presented with bloody diarrhea and underwent a MR-enterography and a colonoscopy.

At colonoscopy, a normal colon was seen, but the ileocecal valve was stenotic.

Scroll through the images.

Severe disease activity can be seen at the terminal ileum with presence of multiple fistulas.
This examination prompted the gastro-enterologist to start anti-TNF treatment.

The Radiology Assistant : Crohn's disease (24) Small abscess medioposterior from thickened and inflamed terminal ileum. Note the rim enhancement on the post-contrast T1 image (upper) and marked mural signal on the fat sat T2 image (lower)


Abscesses are often seen in patients with severe active Crohn's disease.

Abscesses are characterized by rim enhancement on post-contrast T1 images and central high signal intensity on T2 images.

The abscess is frequently surrounded by fat stranding.

Diffusion Imaging

The Radiology Assistant : Crohn's disease (25) Crohn's disease of the terminal ileum with high signal on axial DWI and low signal on ADC map indicating diffusion restriction (b=600).

Diffusion Imaging
Bowel inflammation, fistulas and abscesses show restricted diffusion -high on DWI, low on ADC.
B values of 600 - 1000 are most commonly used.

Maybe DWI can replace contrast-enhanced series, but its role is not defined yet.


How much compensation for Crohn's disease? ›

The maximum monthly benefit for Crohn's is $3,627 under SSDI and $914 under SSI in 2023. The maximum payments for SSDI and SSI are the same for all conditions, regardless of how severe your disability is. But there are some factors that can impact your disability check.

Is having Crohn's a disability? ›

The Social Security Administration classifies Crohn's disease as a disability. A person with Crohn's disease may be able to claim Social Security disability benefits if their condition means they cannot work, as long as they can provide evidence to support their claim.

What are the symptoms of Crohn's disease in radiology? ›

Features that may be discovered during transabdominal sonography include 39:
  • small bowel wall thickening (>3-4 mm) ...
  • affected segments lose peristaltic activity 38
  • loss of mural stratification. ...
  • bowel wall hyperemia. ...
  • hyperechoic, circumferential layer external to the bowel wall. ...
  • mesenteric lymphadenopathy.
May 9, 2023

What is the best radiographic procedure for patients with Crohn's disease? ›

CT should be the first radiologic procedure performed in patients with acute symptoms and suspected or known Crohn disease. The ability to directly demonstrate the bowel wall, adjacent abdominal organs, mesentery, and retroperitoneum makes CT superior to barium studies in diagnosing the complications of Crohn disease.

Can you claim money for Crohn's disease? ›

You will need to show that your Crohn's or Colitis affects your daily life. To claim PIP, you must: Have had problems with daily living activities and/or mobility difficulties for at least three months and. expect these problems to last for at least another nine months (unless you are terminally ill)

What percentage of people with Crohn's are on disability? ›

The overall disability rate in the IBD population was 18.8%, and the RR was 1.8 (95% CI 1.4 to 2.3) for ulcerative colitis (UC) and 2.0 (95% CI 1.4 to 2.7) for Crohn's disease (CD).

How does Crohn's limit your ability to work? ›

The pain may keep you from being able to bend over, squat, or lift and carry items. The inflammation and chronic diarrhea can cause severe pain, fatigue, and weight loss that all result in your ability to stay in one position for perform work for long periods of time.

Can I get a blue badge if I have Crohn's? ›

Despite the fact that Crohn's is eligible for a blue badge under the Department for Transport's advice, it is down to the local authorities' discretion over who can have a blue badge and who cannot. Having Crohn's disease, Paul suffers from stomach cramping and the urgent need to go to the toilet.

Can you get Social Security disability for Crohn's? ›

Inflammatory bowel disease (IBD) is included in the SSA's listing of impairments. Because Crohn's disease is a type of IBD, if you have been diagnosed with this condition, you may qualify for SSDI benefits.

How serious is Crohn's disease? ›

Crohn's disease can be both painful and debilitating, and sometimes may lead to life-threatening complications. There's no known cure for Crohn's disease, but therapies can greatly reduce its signs and symptoms and even bring about long-term remission and healing of inflammation.

What is the number one symptom of Crohn's disease? ›

A type of inflammatory bowel disease (IBD), Crohn's disease causes your digestive tract to become swollen and irritated. If you have Crohn's, you might experience symptoms like abdominal pain, diarrhea, weight loss and rectal bleeding. This is a life-long condition that cannot be cured.

What confirms Crohn's disease? ›

Intestinal endoscopies are the most accurate methods for diagnosing Crohn's disease and ruling out other possible conditions, such as ulcerative colitis, diverticular disease, or cancer. Intestinal endoscopies include the following: Colonoscopy.

What surgery fixes Crohn's disease? ›

Resection. Almost without exception, resection is the procedure of choice for Crohn's disease of the small bowel, especially when it is the patient's first operation.

Does Crohn's disease show up on a blood test? ›

There is no one test to diagnose Crohn's or Colitis. Your GP will consider all of your symptoms, together with your blood and poo test results. To confirm a diagnosis, your GP may send you to have endoscopies, scans or X-rays. Crohn's affects any part of the gut from your mouth to your bottom (anus).

What is the most common surgery for Crohn's disease? ›

The most common type of surgery in people Crohn's disease is laparoscopic ileo-cecal resection, which is a removal of the cecum (the area that connects the small intestine to the large intestine) and the terminal ileum (the end of the small intestine that connects to the large intestine).

Does Crohns qualify for disability credit? ›

SSA lists “Crohn's Disease” as a qualifying condition of the Digestive System, under listing 5.06, Inflammatory Bowel Disease. If the SSA finds objective medical evidence in your record that shows your Crohn's meets the criteria of the listing, the SSA will proceed to approve your claim for disability.

Can I get short term disability for Crohn's? ›

Sometimes, Crohn's disease can make you eligible for disability insurance benefits. During a short-lived flare, you might qualify for short-term disability benefits, which typically cover leaves of absence that are under a year.

Can you work full time with Crohn's disease? ›

If someone is diagnosed early in life their education or early career might be disrupted. However, most people with Crohn's disease are in remission for most of their life, leading full working lives.

How much does Crohn's affect life expectancy? ›

However, people living with inflammatory bowel diseases like Crohn's have a shorter average life expectancy than those who don't. According to the study, females with IBD may live from 6.6 to 8.1 years less than females without IBD. Males with IBD may live from 5.0 to 6.1 years less than males without the condition.

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